2023

Publications (英文)

1. Editorial: Odor information processing and stress response.

Matsukawa M, Fukuda M, Sato T.

Front. Behav. Neurosci. 17:1142186. doi:10.3389/fnbeh.2023.1142186.

2. Serum free fatty acid changes caused by high expression of Stearoyl-CoA desaturase 1 in tumor tissues are early diagnostic markers for ovarian cancer .

Kanoko Katoh, Yuki Katoh, Akiko Kubo, Miho Iida, Yuji Ikeda, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Makoto Suematsu, Shuichi Hirai, Kei Kawana.

Can Res Commun. 2023 3(9):1840-1852. doi: 10.1158/2767-9764.CRC-23-0138.

3. Biogenesis of fibrils requires C-mannosylation of PMEL.

Kawahara R, Usami T, Arakawa S, Kamo H, Suzuki T, Komatsu R, Hara H, Niwa Y, Shimizu E, Dohmae N, Shimizu S, Simizu S.

FEBS J. 2023 Nov;290(22):5373-5394. doi: 10.1111/febs.16927.

4. Macrophage depletion using clodronate liposomes reveals latent dysfunction of the hematopoietic microenvironment associated with persistently imbalanced M1/M2 macrophage polarization in a mouse model of hemophagocytic lymphohistiocytosis.

Koike T, Miura K, Hatta H, Nakamura H, Hirabayashi Y, Yuda M, Harada T, Hirai S, Tsuboi I, Aizawa S.

Annals of Hematology. 2023 Dec;102(12):3311-3323. doi: 10.1007/s00277-023-05425-w.

5. Comparing the effects of microgravity and amyotrophic lateral sclerosis on mouse dorsal root ganglia.

Yoshikawa M, Matsukawa M, Oshima H, Ishikawa C, Li H, Kudo T, Shiba D, Shirakawa M, Muratani M, Takahashi S, Uemura M, Aizawa S, and Shiga T.

Front. Space Technol. 4:1162268. doi:10.3389/frspt.2023.1162268.

6. Phase I/II randomized clinical trial of an oral therapeutic vaccine targeting HPV for treatment of CIN2/3 .

Kei Kawana, Osamu Kobayashi, Yuji Ikeda, Hideaki Yahata, Takashi Iwata, Toyomi Satoh, Azusa Akiyama, Daichi Maeda, Yumiko Hori-Hirose, Yukari Uemura, Kaori Nakayama-Hohoya, Kanoko Katoh, Yuki Katoh, Takahiro Nakajima, Ayumi Taguchi, Atsushi Komatsu, Mikiko Asai-Sato, Naoko Tomita, Kiyoko Kato, Daisuke Aoki, Shizunobu Igimi, Ai Kawana-Tachikawa, Danny J Schust.

JNCI Cancer Spectr. 2023 Oct 31;7(6):pkad101. doi: 10.1093/jncics/pkad101.

7. Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics.

　Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa

Br J Cancer. 2023 May;128(10):1838-1849. doi: 10.1038/s41416-023-02210-4.

8. Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression.

　Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa

PLoS One. 2023 Dec 1;18(12):e0295273. doi: 10.1371/journal.pone.0295273

Publications (和文)

1. Development of chimeric antigen receptor (CAR)-T cell therapy for solid tumors by modulating immunosuppressive tumor microenvironment.

加藤侑希，池田俊勝，加藤果野子, 杉俊洸, 川名敬, 平井宗一

日本大学医学部総合医学研究所紀要

2．COVID-19蔓延下での日本大学医学部徳沢診療所の現状と課題

　　清水翔一,　原田智紀

登山医学 42(1): 21-24

３．山岳診療所を100年企業とするために

　　原田智紀,　清水翔一,　平林幸生　

登山医学 42(1): 29-33

受賞

学会発表

＜シンポジウム・招待講演＞

1. 卵巣がんの早期診断を可能にするリピッドメタボロミクスマーカーの開発

第65回日本婦人科腫瘍学会（野澤記念受賞講演）

加藤侑希, 久保亜紀子, 加藤果野子, 平井宗一, 末松誠, 岩田卓, 川名敬

2. Development of early diagnostic markers for ovarian cancer utilizing metabolic characteristics of cancer cells

12th DSANJ Digital Bio Conference ’23

Yuki Katoh

3. Development of early diagnostic markers for ovarian cancer utilizing fatty acid metabolic properties of cancer patients

BioJapan 2023

Yuki Katoh

4. がん細胞の脂肪酸代謝特性を活用した、高精度がん早期診断法の開発

第３回産学連携研究シーズ発表会

加藤侑希

5. Adoptive cell therapy using autologous tumor-infiltrating lymphocytes in advanced cervical cancer

61st Annual Meeting of the Japan Society of Clinical Oncology

Iwata Takashi, Nishio Hiroshi, Matsui Tomoya, Matsuda Risa, Sugawara Masaki, Fujita Tomonobu, Funakoshi Takeru, Hirai Ikuko, Ohta Shigeki, Kawakami Yutaka, Katoh Yuki, Yamagami Wataru

６. ハーフマラソンで90分を切る運動強度は登山ではどのような体力か？

　第43回一般社団法人日本登山医学会学術集会

　原田智紀

＜一般演題＞

1. Phase I/II randomized clinical trial of an oral therapeutic vaccine targeting HPV; anti-cancer therapy that leverages mucosal immunity.

　35th International Papillomavirus Conference

　Kei Kawana, Yuji Ikeda, Hideaki Yahata, Takashi Iwata, Toyomi Satoh, Azusa Akiyama, Daichi Maeda, Yumiko Hori-Hirose, Yukari Uemura, Ai Kawana-Tachikawa, Kaori Nakayama-Hohoya, Osamu Kobayashi, Ayumi Taguchi, Yuki Katoh, Danny J Schust

2. Serum levels of free fatty acids are useful early diagnostic markers for ovarian cancer.

　The 75th Annual Congress of the Japan Society of Obstetrics and Gynecology

　Toshihiro Sugi, Yuki Katoh, Kanoko Katoh, Nobuki Hayashi, Osamu Kobayashi, Takahiro Nakajima, Mikiko Asai-Sato, Yuji Ikeda, Atsushi Komatsu, Takashi Iwata, Kei Kawana

3. Fatty acid metabolism associated with lympho-vascular space invasion and lymph node metastasis followed by poor prognosis in endometrial cancer.

　The 75th Annual Congress of the Japan Society of Obstetrics and Gynecology

　Risa Yoshida, Yuki Katoh, Osamu Kobayashi, Kanoko Katoh, Takahiro Nakajima, Aiko Aoki, Kaori Kawakami, Yuji Ikeda, Atsushi Komatsu, Keisuke Saito, Mikiko Asai-Sato, Kei Kawana

4. Study on companion diagnostics for a novel immunotherapy targeting HPV16 E7 using lactobacillus-based oral cancer vaccine to leverage mucosal immunity.

　The 75th Annual Congress of the Japan Society of Obstetrics and Gynecology

　Hanano Ando, Yuki Katoh, Yuki Okuma, Kanoko Katoh, Osamu Kobayashi, Takahiro Nakajima, Yuji Ikeda, Kaori Kawakami, Keisuke Saitou, Mikiko Sato, Atsushi Komatsu, Kei Kawana

5. Investigation of serum free fatty acids as novel tumor marker for early detection of cervical cancer.

　The 75th Annual Congress of the Japan Society of Obstetrics and Gynecology

　Nobuki Hayashi, Yuki Katoh, Kanoko Katoh, Takahiro Nakajima, Mikiko Asai-Sato, Yuji Ikeda, Atsushi Komatsu, Takashi Iwata, Kei Kawana

6. Deep learning-based approach to predict multiple genetic mutations in colorectal and lung cancer tissues using hematoxylin and eosin-stained whole-slide images.

　2023 American Society of Clinical Oncology (ASCO) Annual Meeting

　Teppei Konishi, Mateusz Grynkiewicz, Keita Saito, Takuma Kobayashi, Akiteru Goto, Michinobu Umakoshi, Takashi Iwata, Hiroshi Nishio, Yuki Katoh, Tomonobu Fujita, Tomoya Matsui, Masaki Sugawara, Hiroyuki Sano

7. Novel deep learning–based prognostic prediction model for colorectal cancer using hematoxylin and eosin–stained whole slide images.

　2023 American Society of Clinical Oncology (ASCO) Annual Meeting

8. 骨髄造血微小環境におけるM1･M2マクロファージの役割についての検討

　第128回日本解剖学会総会・全国学術集会

　日野浩嗣, 湯田幸, 相澤信, 壷井功, 平林容子, 原田智紀, 平井宗一

9. CDK4/6阻害薬abemaciclibはリソソーム由来の空胞形成を伴った新規細胞死を誘導する

　第6回プログラニュリン研究会

　日野浩嗣, 田中良法, 池田俊勝, 原知世, 竹谷浩介, 高野直治, 平本正樹, 相澤信, 宮澤啓介, 江藤真澄, 平井宗一

10. CDK4/6阻害薬abemaciclibが誘導する細胞死と連動した空胞形成メカニズムの検討

　第96回日本生化学会大会

　日野浩嗣, 田中良法, 池田俊勝, 原知世, 竹谷浩介, 高野直治, 平本正樹, 相澤信, 宮澤啓介, 江藤真澄, 平井宗一

11.　日本人成人馬蹄腎の形態について

　第129回　日本解剖学会総会・全国学術集会

　　内藤美智子、島田和幸

12.　高地肺水腫が疑われて緊急下山を開始し、標高を1000m下げたものの下山決定から10時間ほどで死亡した急速進行の一例

　第43回一般社団法人日本登山医学会学術集会

　原田智紀

特許

1. 粘膜病変患者に対する免疫療法薬による治療の有効性を予測するための方法及びキット (特願2023-005795)

川名敬, 加藤侑希, 瀨脇智満

2. 試料の検査方法、婦人科癌の検査キット及び医薬 (PCT/JP2023/028921)

加藤侑希, 久保亜紀子, 川名敬